Debra A. Tonetti

Debra A. Tonetti, Ph.D.
Associate Professor of Pharmacology
Biopharmaceutical Sciences
University of Illinois at Chicago
833 S. Wood St. m/c 865
Chicago, IL USA 60612
P: (312) 413-1169
F: (312) 996-1698

Lecture Title: Selective Estrogen Mimics for the Treatment of Tamoxifen-Resistant Breast Cancer Using PKC? as a Predictive Biomarker

Debra A. Tonetti obtained a Ph.D. in Biochemistry from Loyola University of Chicago and completed postdoctoral studies at Argonne National Laboratory as an Enrico Fermi Postdoctoral Fellow in the laboratory of Dr. Eli Huberman. Dr. Tonetti moved to Northwestern University and trained with Dr. V. Craig Jordan, where she investigated the mechanism of endocrine resistant breast cancer. In 2001, she joined the faculty in the Department of Biopharmaceutical Sciences at the University of Illinois at Chicago where she is currently an Associate Professor. Her laboratory was the first to report the correlation between endocrine resistant breast cancers with PKC? overexpression. The current focus of her laboratory is the application of a novel class of drugs called Selective Estrogen Mimics (SEMs) using PKC? as a predictive biomarker.

Her discovery of PKC? as a potential predictive biomarker forms the basis of a clinical trial currently open to metastatic breast cancer patients at the University of Illinois at Chicago. She is establishing breast cancer patient-derived xenografts (PDXs) at UIC to perform testing of SEMs and other cancer therapies. She is an Editorial Board member for the International Journal of Breast Cancer and serves on the Breast Cancer Working Group within the UIC Cancer Center. She has also served as an ad hoc panel member for the Department of Defense Breast Cancer Research Program for the past 15 years.