Ping Gao, Ph.D
Professor, School of Life Sciences, USTC,
443 Huangshan Road, Hefei 230027, China
Tel: 86-551-63607033(O) and 86-551-63607012(lab)
Dr. Ping Gao obtained his Ph.D from Osaka University in Japan in 2003. He was trained as a postdoctoral fellow with Dr. Joe Oppenheim in National Cancer Institute of NIH (2003- 2005) and with Dr. Chi V Dang at Johns Hopkins School of Medicine (2005-2007). He was a junior faculty member from 2007 to 2010 in Johns Hopkins School of Medicine, where he studied the mechanisms underlying the neoplastic activities of the cMYC oncogene. His numeric contributions to the field include the illustration of a HIF-dependent Anti-tumorigenic pathway of anti-oxidants in vivo (Gao P et al., Cancer cell 2007) and the discovery highlighting c-myc suppression of mir-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism (Gao P et al Nature 2009). He has been a professor in School of Life Science, USTC since 2010. Gao Lab is currently focused on studying the cellular metabolism, cancer metabolism in particular, to explore the new strategy for cancer therapy.
Selected Publications (*Corresponding author).
1.Cao, Y., Guo, W. T., Tian, S., He, X., Wang, X. W., Liu, X., Gu, K. L., Ma, X., Huang, Hu, L, Cai, Y., Zhang, H., Wang, Y.*, and Gao, P*. miR-290/371-Mbd2-Myc Circuit Regulates Glycolytic Metabolism to Promote Pluripotency. EMBO J. 2015 Jan 20. pii: e201490441.
2.Sun, L. , Song, L. , Wan, Q., Wu, G., Li, X., Wang, Y., Wang, J., Liu, Z., Zhong, X., He, X., Shen, S., Pan, X., Li, A., Wang, Y., Gao, P.*, Tang, H.*, and Zhang, H*. cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation Conditions. Cell Research. 2015 Apr. (In Press)
3.Ma X＃, Li C＃, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P* and Zhang H*. Lin28/let-7 Axis Regulates Aerobic Glycolysis and Cancer Progression via PDK1. Nature Communications 2014 ;5:5212. doi: 10.1038/ncomms6212.
4.He X#, Cao Y, Wang L, Han Y, Zhong X, Zhou G, Cai Y, Zhang H, Gao P*. Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis. PloS one. 2014, 9, e95213.
5.Gao P*, Sun L, He X, Cao Y, Zhang H. MicroRNAs and the Warburg Effect: new players in an old arena. Curr Gene Ther. 12(4), pp285-91, 2012
6.Gao P*, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV*. c-myc suppression of mir-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009 Apr 9;458(7239):762-5.
7.Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA, Semenza GL, Dang CV*. HIF-dependent Anti-tumorigenic Effect of Anti-oxidants In Vivo. Cancer Cell, 2007 Sep;12 (3):230-8.
8.Zhang H, Gao P, Fukuda R, Kumar G, Krishnmachary B, Zeller KI, Dang CV, Semenza GL*. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of c-MYC activity. Cancer Cell, 2007, 11(5):407-20
9.Dang CV*, Kim JW, Gao P, Yustein J. The interplay between MYC and HIF in cancer. Nature Review Cancer . 2008; 8(1): 51-6
10.Gao P, Wange R L, Zhang N, Oppenheim JJ, Howard O M Z*. Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN. Blood 2005; 106(8):2619-26